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2 edition of Extraction and identification of chlorpromazine from urine. found in the catalog.

Extraction and identification of chlorpromazine from urine.

Gordon E. Johnson

Extraction and identification of chlorpromazine from urine.

by Gordon E. Johnson

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  • 9 Currently reading

Published .
Written in English


Edition Notes

Thesis (M.A.) -- University of Toronto, 1959.

The Physical Object
Pagination1 v.
ID Numbers
Open LibraryOL20497643M

A simple and fast solid phase extraction (SPE) method allowing the preconcentration, clean-up, and subsequent separate elution of phenothiazines (chlorpromazine hydrochloride, acetopromazine, and.   Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug. Journal of Pharmacy and Pharmacology , 21 (10), DOI: /jtbx. Ina A. Zingales. Detection of chlorpromazine and thioridazine metabolites in human erythrocytes.

The urine samples from swine farms were all free from tranquilizers, while diazepam was detected in three out of five suspected samples at concentrations of , , and μg/L. The identification of the positive samples was confirmed by comparing the retention time and ion ratio of real samples to that of the matrix-matched standard.   Ceramic carbon materials were developed as new sorbents for solid-phase extraction of organic compounds using chlorpromazine as a representative. The macroporosity and heterogeneity of ceramic carbon materials allow extracting a large amount of chlorpromazine over a short time. Thus, the highly sensitive and selective determination of chlorpromazine in urine .

Part 2. Identification of drugs by principal components analysis of standardized TLC data in four eluent systems and of retention indices on SE 30, J. Anal. Toxicol., 11, , ) NIST Spectra nist ri: (Program type: Isothermal; Col.   A single-step extraction method and thin-layer identification techniques capable of testing a wide variety of drugs of abuse are presented. These techniques are well suited for large and/or small drug programs involved in urine testing because they provide substantial economic benefits and improve clinical functioning.


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Extraction and identification of chlorpromazine from urine by Gordon E. Johnson Download PDF EPUB FB2

Chlorpromazine is detectable in the milk of some mothers during therapy, but levels appear not to correlate well with the maternal dose or serum level. Some breastfed infants become drowsy during maternal chlorpromazine therapy.

Very limited long-term follow-up data indicate no adverse developmental effects when the drug is used alone. However, using it in combination. ISOLATION AND IDENTIFICATION OF URINARY CHLORPROMAZINE METABOLITES IN MAN* C. HUANGt Medical Research Department, Spring Grove State Hospital, Baltimore, Maryland (Accepted 2 June ) Summary--Seventeen chlorpromazine metabotites were isolated from pooled urine of psychotic patients in sufficient quantities for by: Metabolic pathways of chlorpromazine.

were able to find 10 nonconjugated metabolites in human urine by using gas chromatography (microcoulometric detector) (7). In recent years GLC-MS has been successfully used for the identification of, e.g., steroids, hormones, lipids, urinary acids, and terpenes ().Cited by: A simple, rapid and sensitive method termed as magnetic solid phase extraction (MSPE) combined with high-performance liquid chromatography-ultraviolet detector (HPLC-UV) has been proposed for the determination of trace amounts of chlorpromazine (CPZ) in water, urine and plasma by: In this paper we report the isolation and identification of a new chlorpro- mazine metabolite, 2-chloro-l0-(-propionic acid)phenothiaziae, found in urine of mental patients receiving chlorpromazine.

Expe rimental Urine from patients with various mental disorders who were receiving to mg of chlorpromazine per day was used in this by: The method offered acceptable recovery for both human urine (%) and pharmaceutical formulations (%), which was sensitive enough to detect chlorpromazine.

The LOD and LOQ in human. Chlorpromazine is metabolized extensively and at least 12 different metabolites are known. Less than 1% is excreted unchanged. Most metabolites are excreted in the urine as unconjugated or conjugated forms.

The half-life of chlorpromazine is variable at approximately 30 hours. If you have been taking chlorpromazine injection on a regular basis and you stop it all of a sudden, you may have signs of withdrawal.

Do not stop taking chlorpromazine injection all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.

You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. DNA extraction from fresh urine has been described before, yielding DNA usable for PCR analysis in up to 35% of healthy males and up to 75% of healthy females [2,6,7]. Storage of fresh urine at 4°C or lower temperatures results in significant degradation of human DNA, resulting in low recovery rates during long-term storage [ 8 - 13 ].

Fishman et al have reported on the identification of the N-oxide of chlorpromazine in the urine of psy- chiatric patients receiving the drug Thorazine.

Gas-liquid chromatography in this laboratory has shown a peak with a retention time identical with that obtained on chromatographing CPNO, although it is recognized that the N-oxide is not. Chlorpromazine is an antipsychotic from the category of phenothiazines, represents 1 generation of neuroleptics.

Neuroleptic effect develops by blocking the conductors of dopamine inside individual cerebral structures. Thanks to their blockade, pituitary prolactin production increases. Percentage recoveries obtained with direct extraction from urine ± S.D. were 61 ± 4% for morphine C, 86 ± 6% for pentobarbital C, and 61 ± 21% for amphetamine-3 H.

Utilizing direct extraction methods almost all the drugs of abuse could be detected at levels ranging from 1 to 2 μg/ml of urine (15 ml of urine sample). provides accurate and independent information on more t prescription drugs, over-the-counter medicines and natural products.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 30 June ), Cerner Multum™ (updated. The extraction of drugs from biological matrices is an essential specimen preparation step in current forensic postmortem laboratories.

Traditionally, liquid/liquid extractions (LLE) were. This paper describes the electrochemical modification of a pencil graphite fiber used as both a solid phase microextraction fiber and a working electrode in differential pulse voltammetry (DPV). The combination of solid phase microextraction and DPV was applied as a highly selective and sensitive method for the det.

The monitoring of chlorpromazine in the tissue and urine of food-producing animals is very important due to the possibility of its illegal use. For this reason sensitive andselective analytical methods shouldbe usedfor the determination of Extraction of chlorpromazine from samples.

Acetonitrile was usedfor the. Chlorpromazine is a psychiatric medication that belongs to the class of drugs called phenothiazine antipsychotics. It works by helping to restore the balance of certain natural substances in the. A study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (IV) dose (10 mg) and three single oral doses (25, 50 and mg), with a washout period of two weeks between doses.

Plasma levels of CPZ, CPZ N-oxide (CPZNO), CPZ sulfoxide (CPZSO) and both free and conjugated 7-hydroxy-CPZ (7-HOCPZ) were measured by extraction. Curry SH, Derr JE, Maling HM. The physiological disposition of chlorpromazine in the rat and dog. Proc Soc Exp Biol Med.

May; (1)– Curry SH, Marshall JH. Plasma levels of chlorpromazine and some of its relatively non-polar metabolites in psychiatric patients. Life Sci. Jan 1; 7 (1):9– Chlorpromazine hydrochloride Images.

What does Chlorpromazine hydrochloride look like. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi ingredient medications may also be listed when applicable.

Accuracy was evaluated by analyzing urine samples, supplemented with known concentrations of p-aminophenol (,and mg/L), on 15 different days. Again, a “blank” urine pool was used to prepare the samples on a daily basis, starting from a freshly prepared stock solution.

Recovery of added analyte was calculated. Sensitivity.Information about Chlorpromazine, Urine. Search our extensive database of medical/laboratory tests and review in-depth information about each test.

Chlorpromazine, Urine - Medical Laboratory Tests - Seach, Database, Information.Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.

It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting.